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Chemotherapy was potentiated by E7449 and one agent had major antitumor action in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell strains, probably as a result of TNKS inhibition. In keeping with this possibility, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization